Lyra Therapeutics (LYRA) Return on Assets [ROA] (2020 - 2025)
Lyra Therapeutics (LYRA) posted Return on Assets [ROA] of -72.46% for Q4 2025, up 56.32 percentage points from -128.79% a year earlier but down 4.02 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) Return on Assets [ROA] (2020 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics' Return on Assets [ROA] came in at -56.45%, up 32.98 percentage points from FY2024.
- Annual Return on Assets [ROA] shows a five-year change of -10.26 percentage points (FY2020 to FY2025).
- In prior years, Lyra Therapeutics' Return on Assets [ROA] was -89.43% in FY2024 (-39.80 pp), -49.63% in FY2023 (+17.44 pp), -67.07% in FY2022 (-2.94 pp) and -64.13% in FY2021 (-17.94 pp).
- Quarterly Return on Assets [ROA] has run from a low of -129.67% in Q1 2025 to a high of -33.43% in Q1 2021 over five years.
- On a year-over-year basis, Return on Assets [ROA] has increased in each of the last three quarters, with an average year-over-year change of -16.27 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Return on Assets [ROA] in the past five years was Q4 2025, with a gain of 56.32 percentage points; the weakest was Q1 2025, with a drop of 81.19 percentage points.
- According to Business Quant data, Return on Assets [ROA] for the three prior quarters was -68.44% (Q3 2025), -71.33% (Q2 2025) and -129.67% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 20.64% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 10.47% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 4.65% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 2.45% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 28.37% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 9.10% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 9.29% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -6.13% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 2.14% |
| 10 | Lyra Therapeutics | 266,232.31 | 266,232.31 | - | -72.46% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -72.46% |
| Sep 30, 2025 | -68.44% |
| Jun 30, 2025 | -71.33% |
| Mar 31, 2025 | -129.67% |
| Dec 31, 2024 | -128.79% |
| Sep 30, 2024 | -112.63% |
| Jun 30, 2024 | -85.88% |
| Mar 31, 2024 | -48.48% |
| Dec 31, 2023 | -47.63% |
| Sep 30, 2023 | -50.15% |
| Jun 30, 2023 | -55.44% |
| Mar 31, 2023 | -58.49% |
| Dec 31, 2022 | -48.18% |
| Sep 30, 2022 | -43.82% |
| Jun 30, 2022 | -57.45% |
| Mar 31, 2022 | -93.18% |
| Dec 31, 2021 | -70.97% |
| Sep 30, 2021 | -51.24% |
| Jun 30, 2021 | -43.14% |
| Mar 31, 2021 | -33.43% |
API Access
Lyra Therapeutics Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();