Ionis Pharmaceuticals (IONS) Return on Invested Capital [ROIC] (2010 - 2026)
Ionis Pharmaceuticals (IONS) reported Return on Invested Capital [ROIC] of -87.17% for Q2 2026, down 49.56 percentage points from the prior quarter.
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Analysis
Ionis Pharmaceuticals (IONS) Return on Invested Capital [ROIC] (2010 - 2026) Analysis & Trends
For FY2025, Ionis Pharmaceuticals posted Return on Invested Capital [ROIC] of -48.03%, up 36.19 percentage points from FY2024.
- Return on Invested Capital [ROIC] has a five-year change of -35.51 percentage points (FY2020 to FY2025).
- By year, Return on Invested Capital [ROIC] came in at -84.21% in FY2024 (-17.58 pp), -66.63% in FY2023 (-9.02 pp), -57.62% in FY2022 (-54.58 pp) and -3.04% in FY2021 (+9.48 pp).
- The Q2 2026 figure ranks as the lowest quarterly Return on Invested Capital [ROIC] since Q2 2024.
- The high point for year-over-year Return on Invested Capital [ROIC] in five years was Q3 2025 (a gain of 51.03 percentage points); the low point was Q1 2023 (a drop of 86.65 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at -37.61% (Q1 2026), -34.73% (Q4 2025) and -21.95% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROIC (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 37.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 16.10% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 18.68% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | 3.56% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 21.95% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 28.83% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 14.33% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 13.44% |
| 10 | Ionis Pharmaceuticals | 7.21 Bn | -1.68 Bn | 265.21 Mn | -87.17% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -87.17% |
| Mar 31, 2026 | -37.61% |
| Dec 31, 2025 | -34.73% |
| Sep 30, 2025 | -21.95% |
| Dec 31, 2024 | -69.59% |
| Sep 30, 2024 | -72.98% |
| Jun 30, 2024 | -112.48% |
| Mar 31, 2024 | -95.63% |
| Mar 31, 2023 | -86.11% |
| Dec 31, 2022 | -65.78% |
| Sep 30, 2022 | 1.75% |
| Jun 30, 2022 | -1.13% |
| Mar 31, 2022 | 0.53% |
| Dec 31, 2021 | -3.99% |
| Sep 30, 2021 | -40.30% |
| Jun 30, 2021 | -29.75% |
| Mar 31, 2021 | -21.20% |
| Dec 31, 2020 | -12.75% |
| Sep 30, 2020 | 4.09% |
| Jun 30, 2020 | 7.93% |
API Access
Ionis Pharmaceuticals Return on Invested Capital [ROIC] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-invested-capital-%5Broic%5D&ticker=IONS&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-invested-capital-[roic]", "ticker": "IONS", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-invested-capital-%5Broic%5D&ticker=IONS&period=max&api_key=YOUR_API_KEY");
const data = await res.json();