CASI Pharmaceuticals (CASIF) Operating Margin (2022 - 2025)
CASI Pharmaceuticals (CASIF) recorded Operating Margin of -1068.86% in Q4 2025, down 972.17 percentage points from -96.69% a year earlier and down 721.64 percentage points from the prior quarter.
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Analysis
CASI Pharmaceuticals (CASIF) Operating Margin (2022 - 2025) Analysis & Trends
For FY2025, CASI Pharmaceuticals reported Operating Margin of -217.30%, down 78.46 percentage points from FY2024.
- Annual Operating Margin has a five-year change of +131.30 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -138.84% in FY2024 (-64.81 pp), -74.03% in FY2023 (+4.92 pp), -78.95% in FY2022 (+58.67 pp) and -137.62% in FY2021 (+210.98 pp).
- The Q4 2025 figure is the lowest quarterly Operating Margin in data going back to Q1 2022.
- On a year-over-year basis, Operating Margin has declined for three consecutive quarters, with an average year-over-year change of -194.97 percentage points over the last eight quarters.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 110.99 percentage points in Q1 2025, against a drop of 972.17 percentage points in Q4 2025 at the low end.
- Per Business Quant, the preceding three quarters came in at -347.22% (Q3 2025), -266.47% (Q2 2025) and -166.33% (Q1 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | CASI Pharmaceuticals | 2.67 Mn | -18.15 Mn | - | - |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -1,068.86% |
| Sep 30, 2025 | -347.22% |
| Jun 30, 2025 | -266.47% |
| Mar 31, 2025 | -166.33% |
| Dec 31, 2024 | -96.69% |
| Sep 30, 2024 | -108.61% |
| Jun 30, 2024 | -220.88% |
| Mar 31, 2024 | -277.32% |
| Dec 31, 2023 | -49.85% |
| Sep 30, 2023 | -57.65% |
| Jun 30, 2023 | -95.16% |
| Mar 31, 2023 | -86.41% |
| Dec 31, 2022 | -98.09% |
| Sep 30, 2022 | -55.98% |
| Jun 30, 2022 | -74.55% |
| Mar 31, 2022 | -76.77% |
API Access
CASI Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=CASIF&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "CASIF", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=CASIF&period=max&api_key=YOUR_API_KEY");
const data = await res.json();