CASI Pharmaceuticals (CASIF) Operating Margin (2022 - 2025)
CASI Pharmaceuticals (CASIF) reported Operating Margin of 1068.86% for Q4 2025, down 97217.0% on a YoY basis from N/an in Q4 2024, and down 207.83% quarter-over-quarter from 347.22% in Q3 2025.
CASI Pharmaceuticals (CASIF) Operating Margin (2022 - 2025) Analysis & Trends
CASI Pharmaceuticals has reported Operating Margin for 4 years, with the latest figure at 1068.86% in Q4 2025.
- For the quarter ending Q4 2025, Operating Margin fell 97217.0% year-over-year to 1068.86%; the trailing twelve-month figure through Dec 2025 stood at 528.07% (down 38923.0% YoY), and the FY2025 full-year result was 217.3%, down 7846.0% from the prior year.
- Operating Margin for Q4 2025 stood at 1068.86%, down from 347.22% in the prior quarter.
- The five-year high for Operating Margin was 234.68% in Q4 2023, with the low at 1068.86% in Q4 2025.
- Historically, Operating Margin has averaged 181.91% across 4 years, with a median of 102.65% in 2024.
- Annual changes were most pronounced in 2023 — Operating Margin soared 38057 bps — and 2025, when it plunged 97217 bps.
- CASI Pharmaceuticals' Operating Margin stood at 145.89% in 2022, then jumped by 261 bps to 234.68% in 2023, then slumped by 141 bps to 96.69% in 2024, then sank by 1005 bps to 1068.86% in 2025.
- The last three Operating Margin figures came in at 1068.86% (Q4 2025), 347.22% (Q3 2025), and 266.47% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 860,679.92 Bn | 860,679.89 Bn | - | - |
| 2 | Belite Bio | 55,284.00 Bn | 55,284.00 Bn | - | - |
| 3 | Quantum Biopharma | 16,206.94 Bn | 16,206.93 Bn | - | - |
| 4 | Legend Biotech | 3,318.00 Bn | 3,317.71 Bn | 242.10 Mn | -6.43% |
| 5 | Akari Therapeutics | 1,543.84 Bn | 1,543.84 Bn | - | - |
| 6 | Evaxion A | 1,449.11 Bn | 1,449.09 Bn | - | - |
| 7 | Psyence Biomedical | 216.99 Bn | 216.98 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 115.22 Bn | 107.97 Bn | 2.59 Bn | 38.10% |
| 9 | Abivax | 90.58 Bn | 90.58 Bn | - | - |
| 10 | CASI Pharmaceuticals | - | - | 3.69 Mn | -1,068.86% |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -1,068.86% |
| Sep 30, 2025 | -347.22% |
| Jun 30, 2025 | -266.47% |
| Mar 31, 2025 | -166.33% |
| Dec 31, 2024 | -96.69% |
| Sep 30, 2024 | -108.61% |
| Jun 30, 2024 | -220.88% |
| Mar 31, 2024 | -277.32% |
| Dec 31, 2023 | 234.68% |
| Sep 30, 2023 | -57.65% |
| Jun 30, 2023 | -95.16% |
| Mar 31, 2023 | -86.41% |
| Dec 31, 2022 | -145.89% |
| Sep 30, 2022 | -55.98% |
| Jun 30, 2022 | -74.75% |
| Mar 31, 2022 | -77.09% |