EW vs ISRG vs MCK Stock Comparison

Edwards Lifesciences, Intuitive Surgical and Mckesson Prices as of Oct 27, 2026 Peers: Industry group
EW Edwards Lifesciences Corp
$90.81 +5.2% 1M +12.4% 1Y
Market cap
$52.36B
P/E
52.1x
Revenue (TTM)
$6.51B
Div. yield
–
Medical Devices Healthcare
2 wins
ISRG Intuitive Surgical Inc
$445.88 +10.0% 1M -19.1% 1Y
Market cap
$154.54B
P/E
52.6x
Revenue (TTM)
$11.58B
Div. yield
–
Medical Devices Healthcare
4 wins
MCK Mckesson Corp
$967.03 +11.6% 1M +19.2% 1Y
Market cap
$112.75B
P/E
25.0x
Revenue (TTM)
$410.98B
Div. yield
0.35%
Drug Distribution Healthcare
5 wins

Head to Head

11 decided of 12

Mckesson leads on 5 of the 12 questions below (Mckesson 5, Intuitive Surgical 4, Edwards Lifesciences 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionEWISRGMCKLeader
Larger companyMarket capitalisation $52.36B $154.54B $112.75B ISRG
Cheaper on earningsLower P/E, profitable companies only 52.1x 52.6x 25.0x MCK
Cheaper on forward earningsLower price / next fiscal year consensus EPS 32.1x 38.9x 20.5x MCK
Faster revenue growthRevenue growth, trailing twelve months +14.6% +20.5% +8.8% ISRG
More profitableNet margin, trailing twelve months 15.4% 25.5% 1.1% ISRG
Better return on capitalReturn on invested capital 9.0% — 107.9% MCK
Less leveragedLower net debt / EBITDA -2.3x — 0.6x EW
Higher dividend yieldTrailing dividend yield — — 0.35% –
Better 1-year returnPrice return, last 12 months +12.4% -19.1% +19.2% MCK
Better 5-year returnAnnualised price return, 5 years -4.9%/yr +4.6%/yr +36.4%/yr MCK
Less volatileAnnualised volatility, 1 year 24.7% 34.6% 30.7% EW
Higher overall scoreMean of the five percentile scores vs peers 78/100 80/100 57/100 ISRG

Percentile Scorecard

EWISRGMCK

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisEWISRGMCK
Valuation 64 #83 of 227 54 #106 of 227 50 #13 of 25
Growth 55 #100 of 219 80 #45 of 219 65 #9 of 24
Profitability 95 #12 of 206 98 #6 of 206 61 #10 of 24
Financial Health 87 #31 of 238 78 #53 of 238 52 #13 of 26
Shareholder Returns 88 #17 of 134 92 #12 of 134 57 #7 of 15
Overall 78 80 57
  • EW ranked among 247 companies in Medical Devices and Diagnostics
  • ISRG ranked among 247 companies in Medical Devices and Diagnostics
  • MCK ranked among 27 companies in Healthcare Payers and Distributors

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodEWISRGMCKSPY
1 month +5.2%+10.0%+11.6% -0.2%
3 months +8.5%+23.2%+8.7% +3.9%
6 months +10.4%-4.4%+15.8% +8.2%
Year to date +6.5%-21.3%+17.9% +12.9%
1 year +12.4%-19.1%+19.2% +12.3%
3 years +47.2%+72.2%+115.8% +87.4%
3 years, per year +13.8%+19.9%+29.3% +23.3%
5 years -22.1%+25.4%+371.7% +67.9%
5 years, per year -4.9%+4.6%+36.4% +10.9%
10 years +195.5%+505.1%+502.5% +261.1%
10 years, per year +11.4%+19.7%+19.7% +13.7%

Risk

MeasureEWISRGMCKSPY
Volatility, 1Y 24.7%34.6%30.7% 12.7%
Downside volatility, 1Y 24.5%37.4%27.4% 12.7%
Beta vs S&P 500, 1Y 0.580.89-0.27 1.00
Return / volatility, 1Y 0.50-0.550.62 0.97
Max drawdown, 5Y -54.3%-49.9%-27.2% -25.4%
From 52-week high -4.6%-24.8%-6.1% -1.2%
52-week high $95.17$592.85$1,030.18 $779.14
52-week low $75.87$332.02$725.17 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleEWISRGMCK
P/E now vs peer median 52.1xmedian 29.6x 52.6xmedian 29.6x 25.0xmedian 23.9x
P/S now vs peer median 8.0xmedian 2.9x 13.3xmedian 2.9x 0.3xmedian 0.3x
EV/EBITDA now vs peer median 30.2xmedian 17.4x 36.8xmedian 17.4x 16.2xmedian 13.4x
P/FCF now vs peer median 36.5xmedian 22.3x 43.0xmedian 22.3x 17.6xmedian 15.5x
P/B now vs peer median 4.9xmedian 2.3x 9.6xmedian 2.3x -26.6xmedian 2.5x
PEG now vs peer median -6.07median 1.04 2.05median 1.04 2.09median 1.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsEWISRGMCK
Revenue $6.51B $11.58B $410.98B
Gross profit $5.07B $7.78B $14.96B
Operating income $1.45B $3.28B $6.50B
Net income $1.00B $2.97B $5.30B
Free cash flow $1.43B $3.60B $6.42B
R&D $1.09B $1.49B –
EPS (diluted) $1.74 $8.41 $38.52
Cash & equivalents $2.91B $2.98B $5.16B
Total debt $598.70M – $9.73B
Shares (diluted) 577.60M 351.60M 119.20M
Enterprise value $36.48B $134.96B $99.21B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricEWISRGMCK
P/E 52.1x 52.6x 25.0x
P/FCF 36.5x 43.0x 17.6x
P/Operating cash flow 30.4x 37.8x 16.5x
P/S 8.0x 13.3x 0.3x
P/B 4.9x 9.6x -26.6x
P/Tangible book 5.6x 10.4x -13.7x
EV/EBITDA 30.2x 36.8x 16.2x
EV/EBIT 33.6x 45.8x 18.1x
EV/Revenue 7.5x 13.0x 0.3x
EV/FCF 34.0x 41.8x 18.3x
EV/Operating cash flow 28.3x 36.8x 17.1x
PEG (3Y EPS CAGR) -6.07 2.05 2.09

Growth

14 metrics
MetricEWISRGMCK
Revenue growth (1Y) 14.6% 20.5% 8.8%
Revenue CAGR (3Y) 15.3% 19.1% 13.1%
Gross profit growth (1Y) 13.0% 21.9% 11.2%
Gross profit CAGR (3Y) 11.9% 19.5% 6.6%
Operating income growth (1Y) -1.4% 16.6% 46.6%
Operating income CAGR (3Y) 5.0% 24.8% 13.5%
Net income growth (1Y) -75.8% 7.5% 58.1%
Net income CAGR (3Y) -10.2% 24.4% 10.7%
EPS growth (1Y) -75.3% 10.8% 52.8%
EPS CAGR (3Y) -8.6% 25.7% 12.0%
Operating cash flow growth (1Y) 116.4% 38.1% 4.7%
Operating cash flow CAGR (3Y) 22.3% 26.4% 10.7%
Free cash flow growth (1Y) 143.9% 58.4% 6.8%
Free cash flow CAGR (3Y) 26.9% 42.0% 11.3%

Profitability

14 metrics
MetricEWISRGMCK
Gross margin 77.8% 67.2% 3.6%
EBITDA margin 24.8% 35.3% 1.8%
Operating margin 22.3% 28.4% 1.6%
Pretax margin 21.8% 31.3% 1.6%
Net margin 15.4% 25.5% 1.1%
FCF margin 22.0% 31.1% 1.6%
Operating cash flow margin 26.4% 35.3% 1.7%
Return on equity 9.5% 17.3% –
Return on assets 7.4% 14.8% 6.2%
Return on invested capital 9.0% – 107.9%
Return on capital employed 12.0% 18.7% 43.4%
Asset turnover 0.5x 0.6x 4.8x
Cash conversion (OCF / net income) 1.7x 1.4x 1.3x
Stock comp / revenue 2.6% 7.2% –

Financial Health

11 metrics
MetricEWISRGMCK
Debt / assets 4.3% – 11.0%
Debt / equity 0.1x – -2.3x
Net debt / EBITDA -2.3x – 0.6x
Debt / FCF 0.4x – 1.5x
Liabilities / assets 22.7% 16.7% 104.8%
Equity / assets 77.3% 83.3% -4.8%
Interest coverage – – 23.6x
Current ratio 4.5x 3.3x 0.9x
Quick ratio 3.5x 2.3x 0.5x
Cash ratio 2.8x 1.6x 0.1x
Altman Z-score 12.77 30.55 5.89

Shareholder Returns

7 metrics
MetricEWISRGMCK
Dividend yield – – 0.4%
Net buyback yield 1.9% 2.8% 5.9%
Shareholder yield 1.9% 2.8% 6.2%
Payout ratio (earnings) – – 7.4%
Payout ratio (FCF) – – 6.1%
Dividend growth (1Y) – – 11.3%
Dividend CAGR (3Y) – – 10.0%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusEWISRGMCK
Forward P/E 32.1xFY2026 38.9xFY2026 20.5xFY2026
EPS, next fiscal year $2.83FY2026 $11.47FY2026 $47.15FY2026
EPS growth, next FY +10.5%FY2026 +28.4%FY2026 +20.6%FY2026
EPS growth, the year after +12.7% +4.5% +11.0%
Revenue, next fiscal year $7.24BFY2026 $11.60BFY2026 $444.47BFY2026
Revenue growth, next FY +19.2%FY2026 +15.3%FY2026 +10.2%FY2026
Revenue growth, the year after -2.6% +11.3% +1.5%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersEWISRGMCK
Held by institutions 90.6% 86.2% 89.1%
Institutions holding 1,323 2,235 2,009
Change in shares held, QoQ +20.4% +4.6% -0.7%
Institutions buying 641 1,070 881
Institutions selling 453 877 791
Buyers to sellers 1.42 1.22 1.11

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

EWISRGMCK
EW 1.00 0.45 0.13
ISRG 0.45 1.00 0.11
MCK 0.13 0.11 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, EW, ISRG and MCK?

Intuitive Surgical (ISRG) is the largest by market capitalisation: Edwards Lifesciences (EW) $52.36B, Intuitive Surgical (ISRG) $154.54B, Mckesson (MCK) $112.75B.

Which stock is cheaper, EW, ISRG and MCK?

Mckesson (MCK) trades on the lowest price-to-earnings ratio (Edwards Lifesciences (EW) 52.1x, Intuitive Surgical (ISRG) 52.6x, Mckesson (MCK) 25.0x). On next year's consensus earnings, Mckesson (MCK) is cheapest (Edwards Lifesciences (EW) 32.1x, Intuitive Surgical (ISRG) 38.9x, Mckesson (MCK) 20.5x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Intuitive Surgical (ISRG) grew revenue fastest over the trailing twelve months: Edwards Lifesciences (EW) +14.6%, Intuitive Surgical (ISRG) +20.5%, Mckesson (MCK) +8.8%.

Which company is more profitable?

Intuitive Surgical (ISRG) has the highest net margin (Edwards Lifesciences (EW) 15.4%, Intuitive Surgical (ISRG) 25.5%, Mckesson (MCK) 1.1%). On return on invested capital, Mckesson (MCK) leads (Edwards Lifesciences (EW) 9.0%, Mckesson (MCK) 107.9%).

Which stock has performed better?

Over the past year Mckesson (MCK) returned the most: Edwards Lifesciences (EW) +12.4%, Intuitive Surgical (ISRG) -19.1%, Mckesson (MCK) +19.2%. Over five years, Mckesson (MCK) compounded fastest (Edwards Lifesciences (EW) -4.9%/yr, Intuitive Surgical (ISRG) +4.6%/yr, Mckesson (MCK) +36.4%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Mckesson (MCK) 0.35%. Edwards Lifesciences (EW) and Intuitive Surgical (ISRG) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Edwards Lifesciences (EW) has been the steadiest (Edwards Lifesciences (EW) 24.7%, Intuitive Surgical (ISRG) 34.6%, Mckesson (MCK) 30.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, EW, ISRG and MCK?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Mckesson (MCK) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.