AMGN vs ARGX vs BIIB Stock Comparison

Amgen, Argenx Se and Biogen Prices as of Oct 23, 2026 Peers: Industry group
AMGN Amgen Inc
$439.26 +8.2% 1M +50.0% 1Y
Market cap
$240.04B
P/E
27.5x
Revenue (TTM)
$38.10B
Div. yield
0.02%
Biotechnology Healthcare
4 wins
ARGX Argenx Se
$873.71 -7.6% 1M +7.6% 1Y
Market cap
$53.25B
P/E
28.4x
Revenue (TTM)
$5.82B
Div. yield
–
Biotechnology Healthcare
4 wins
BIIB Biogen Inc.
$250.69 +10.2% 1M +67.0% 1Y
Market cap
$37.29B
P/E
44.7x
Revenue (TTM)
$10.03B
Div. yield
–
Biotechnology Healthcare
3 wins

Head to Head

11 decided of 12

Amgen leads on 4 of the 12 questions below (Amgen 4, Argenx Se 4, Biogen 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNARGXBIIBLeader
Larger companyMarket capitalisation $240.04B $53.25B $37.29B AMGN
Cheaper on earningsLower P/E, profitable companies only 27.5x 28.4x 44.7x AMGN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 20.1x 28.0x 19.5x BIIB
Faster revenue growthRevenue growth, trailing twelve months +9.1% +61.5% +0.3% ARGX
More profitableNet margin, trailing twelve months 23.0% 32.3% 8.3% ARGX
Better return on capitalReturn on invested capital 14.3% — -5.9% AMGN
Less leveragedLower net debt / EBITDA 2.7x — 0.6x BIIB
Higher dividend yieldTrailing dividend yield 0.02% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +50.0% +7.6% +67.0% BIIB
Better 5-year returnAnnualised price return, 5 years +16.0%/yr +24.4%/yr -1.1%/yr ARGX
Less volatileAnnualised volatility, 1 year 29.6% 36.9% 34.0% AMGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 92/100 65/100 ARGX

Percentile Scorecard

AMGNARGXBIIB

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNARGXBIIB
Valuation 85 #92 of 624 84 #99 of 624 91 #55 of 624
Growth 62 #231 of 603 95 #34 of 603 33 #406 of 603
Profitability 94 #32 of 555 98 #10 of 555 86 #81 of 555
Financial Health 22 #512 of 657 – 52 #314 of 657
Shareholder Returns 68 #118 of 370 – –
Overall 66 92 65
  • AMGN ranked among 671 companies in Pharmaceuticals and Biotechnology
  • ARGX ranked among 671 companies in Pharmaceuticals and Biotechnology
  • BIIB ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNARGXBIIBSPY
1 month +8.2%-7.6%+10.2% -1.0%
3 months +16.8%-4.8%+24.0% +2.9%
6 months +27.5%+12.0%+36.0% +6.4%
Year to date +34.2%+3.9%+42.4% +11.4%
1 year +50.0%+7.6%+67.0% +13.1%
3 years +59.1%+81.6%-0.6% +79.4%
3 years, per year +16.7%+22.0%-0.2% +21.5%
5 years +109.9%+198.0%-5.3% +67.7%
5 years, per year +16.0%+24.4%-1.1% +10.9%
10 years +177.1%—-13.7% +255.2%
10 years, per year +10.7%—-1.5% +13.5%

Risk

MeasureAMGNARGXBIIBSPY
Volatility, 1Y 29.6%36.9%34.0% 12.7%
Downside volatility, 1Y 27.6%34.8%32.2% 12.7%
Beta vs S&P 500, 1Y 0.440.400.26 1.00
Return / volatility, 1Y 1.690.211.97 1.03
Max drawdown, 5Y -26.7%-38.2%-64.4% -25.4%
From 52-week high -1.8%-17.5%-1.2% -2.5%
52-week high $447.28$1,058.90$253.84 $779.14
52-week low $291.16$663.93$147.86 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNARGXBIIB
P/E now vs peer median 27.1xmedian 17.2x 28.5xmedian 17.2x 44.4xmedian 17.2x
P/S now vs peer median 6.2xmedian 8.8x 9.3xmedian 8.8x 3.7xmedian 8.8x
EV/EBITDA now vs peer median 17.4xmedian 16.0x —median 16.0x -48.5xmedian 16.0x
P/FCF now vs peer median 23.3xmedian 17.8x —median 17.8x 13.7xmedian 17.8x
P/B now vs peer median 20.3xmedian 2.1x —median 2.1x 2.0xmedian 2.1x
PEG now vs peer median 10.23median 0.32 0.27median 0.32 -1.36median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNARGXBIIB
Revenue $38.10B $5.82B $10.03B
Gross profit $26.48B $5.24B $7.42B
Operating income $11.43B $1.74B -$1.60B
Net income $8.74B $1.88B $834.60M
Free cash flow $10.18B – $2.70B
R&D $7.63B $1.80B $2.01B
EPS (diluted) $16.07 $28.43 $5.61
Cash & equivalents $13.99B – $1.29B
Total debt $57.30B – $800.00M
Shares (diluted) 544.00M 66.03M 148.70M
Enterprise value $195.44B $53.25B $23.94B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNARGXBIIB
P/E 27.1x 28.5x 44.4x
P/FCF 23.3x – 13.7x
P/Operating cash flow 19.0x – 12.9x
P/S 6.2x 9.3x 3.7x
P/B 20.3x – 2.0x
P/Tangible book -27.0x – 6.9x
EV/EBITDA 17.4x – -48.5x
EV/EBIT 24.6x 31.1x -22.9x
EV/Revenue 7.4x 9.3x 3.6x
EV/FCF 27.6x – 13.6x
EV/Operating cash flow 22.5x – 12.7x
PEG (3Y EPS CAGR) 10.23 0.27 -1.36

Growth

14 metrics
MetricAMGNARGXBIIB
Revenue growth (1Y) 9.1% 61.5% 0.3%
Revenue CAGR (3Y) 12.7% 80.5% 0.2%
Gross profit growth (1Y) 17.6% 62.2% -1.6%
Gross profit CAGR (3Y) 10.3% 80.0% -1.1%
Operating income growth (1Y) 39.5% 120.6% -142.3%
Operating income CAGR (3Y) 6.4% 85.1% -57.9%
Net income growth (1Y) 32.1% 22.5% -45.5%
Net income CAGR (3Y) 3.1% 115.5% -32.1%
EPS growth (1Y) 31.4% 20.9% -46.2%
EPS CAGR (3Y) 2.7% 104.8% -32.6%
Operating cash flow growth (1Y) 3.9% – 36.0%
Operating cash flow CAGR (3Y) 4.9% – 26.3%
Free cash flow growth (1Y) -4.1% – 36.3%
Free cash flow CAGR (3Y) 1.7% – 33.0%

Profitability

14 metrics
MetricAMGNARGXBIIB
Gross margin 69.5% 90.0% 74.0%
EBITDA margin 42.2% – -7.5%
Operating margin 30.0% 29.9% -15.9%
Pretax margin 27.0% 32.6% 10.1%
Net margin 23.0% 32.3% 8.3%
FCF margin 26.7% – 26.9%
Operating cash flow margin 32.8% – 28.7%
Return on equity 83.8% – 4.5%
Return on assets 9.3% – 2.7%
Return on invested capital 14.3% – -5.9%
Return on capital employed 16.7% – -5.9%
Asset turnover 0.4x – 0.3x
Cash conversion (OCF / net income) 1.4x – 3.4x
Stock comp / revenue 1.3% – 3.0%

Financial Health

11 metrics
MetricAMGNARGXBIIB
Debt / assets 59.9% – 2.5%
Debt / equity 4.9x – 0.0x
Net debt / EBITDA 2.7x – 0.6x
Debt / FCF 5.6x – 0.3x
Liabilities / assets 87.8% – 41.3%
Equity / assets 12.2% – 58.7%
Interest coverage 4.3x 10,120x –
Current ratio 1.4x – 1.9x
Quick ratio 0.9x – 1.1x
Cash ratio 0.5x – 0.3x
Altman Z-score 2.28 – 2.87

Shareholder Returns

7 metrics
MetricAMGNARGXBIIB
Dividend yield 2.3% – –
Net buyback yield – – –
Shareholder yield 2.3% – –
Payout ratio (earnings) 60.4% – –
Payout ratio (FCF) 51.9% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.7% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNARGXBIIB
Forward P/E 20.1xFY2026 28.0xFY2026 19.5xFY2026
EPS, next fiscal year $21.80FY2026 $31.22FY2026 $12.86FY2026
EPS growth, next FY -0.2%FY2026 +59.5%FY2026 -15.8%FY2026
EPS growth, the year after +7.3% +29.0% +36.6%
Revenue, next fiscal year $41.51BFY2026 $5.97BFY2026 $9.95BFY2026
Revenue growth, next FY +12.9%FY2026 +40.4%FY2026 +0.6%FY2026
Revenue growth, the year after +2.2% +21.7% +11.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNARGXBIIB
Held by institutions 82.7% 46.1% 96.4%
Institutions holding 3,159 504 1,036
Change in shares held, QoQ +4.5% -2.0% +6.0%
Institutions buying 1,451 264 548
Institutions selling 1,217 160 294
Buyers to sellers 1.19 1.65 1.86

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNARGXBIIB
AMGN 1.00 0.31 0.49
ARGX 0.31 1.00 0.21
BIIB 0.49 0.21 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, AMGN, ARGX and BIIB?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $240.04B, Argenx Se (ARGX) $53.25B, Biogen (BIIB) $37.29B.

Which stock is cheaper, AMGN, ARGX and BIIB?

Amgen (AMGN) trades on the lowest price-to-earnings ratio (Amgen (AMGN) 27.5x, Argenx Se (ARGX) 28.4x, Biogen (BIIB) 44.7x). On next year's consensus earnings, Biogen (BIIB) is cheapest (Amgen (AMGN) 20.1x, Argenx Se (ARGX) 28.0x, Biogen (BIIB) 19.5x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Argenx Se (ARGX) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Argenx Se (ARGX) +61.5%, Biogen (BIIB) +0.3%.

Which company is more profitable?

Argenx Se (ARGX) has the highest net margin (Amgen (AMGN) 23.0%, Argenx Se (ARGX) 32.3%, Biogen (BIIB) 8.3%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 14.3%, Biogen (BIIB) -5.9%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Amgen (AMGN) +50.0%, Argenx Se (ARGX) +7.6%, Biogen (BIIB) +67.0%. Over five years, Argenx Se (ARGX) compounded fastest (Amgen (AMGN) +16.0%/yr, Argenx Se (ARGX) +24.4%/yr, Biogen (BIIB) -1.1%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Amgen (AMGN) 0.02%, Argenx Se (ARGX) 0.00%, Biogen (BIIB) 0.00%. Argenx Se (ARGX) and Biogen (BIIB) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Amgen (AMGN) 29.6%, Argenx Se (ARGX) 36.9%, Biogen (BIIB) 34.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, ARGX and BIIB?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.