Soleno Therapeutics Inc (SLNO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

41,951,872Shares Outstanding

221,094Shares held by institutions

$8,512,119Value of institutional holdings

146.10%Institutional ownership %

11.62%Shares Changed QoQ

238No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Soleno Therapeutics Inc (NASDAQ:SLNO) includes 238 filers as of the latest reporting cycle ending December 2025.

The percentage of Soleno Therapeutics owned by institutions changed from 161.8% in September 2025 to 146.1% in December 2025, marking a slight down trend.
On a quarter-over-quarter basis, institutional holdings shifted by 11.62%, with a year-over-year an increase of 44.24% in the count of filers.
A review of institutional activity for Soleno Therapeutics shows 158 of 238 filers increasing their positions, while 64 reduced their stake, and 16 remained unchanged.
The aggregate institutional position in Soleno Therapeutics now stands at 61.29Mn shares as of December 2025, after investors increased their holdings (up by 6.38Mn shares quarter on quarter which is up 8.34Mn shares year over year).
FMR LLC's holding of 8.08Mn shares as of December 31, 2025 makes it the primary institutional investor in Soleno Therapeutics, owning 19.26% of the stock.
Among the most significant buyers of Soleno Therapeutics during December 2025 were JANUS HENDERSON GROUP PLC (1.12Mn), WELLINGTON MANAGEMENT GROUP LLP (1.01Mn), Deep Track Capital, LP (1.00Mn), Woodline Partners LP (840.95K), READYSTATE ASSET MANAGEMENT LP (668.64K).
Leading sellers of Soleno Therapeutics stock in December 2025 included Vivo Capital, LLC (1.38Mn), Caption Management, LLC (1.00Mn), Artia Global Partners LP (760.65K), Capital World Investors (678.99K), BALYASNY ASSET MANAGEMENT L.P. (432.81K).
The top 10 institutional holders of Soleno Therapeutics for the quarter ending December 2025 included FMR LLC (8.08Mn), JANUS HENDERSON GROUP PLC (7.18Mn), BlackRock, Inc. (3.87Mn), WELLINGTON MANAGEMENT GROUP LLP (3.32Mn), VANGUARD GROUP INC (3.06Mn), Avoro Capital Advisors LLC (2.90Mn), STATE STREET CORP (2.65Mn), Nantahala Capital Management, LLC (1.31Mn), MILLENNIUM MANAGEMENT LLC (1.27Mn), Commodore Capital LP (1.20Mn).

238 Institutional Holders

221,094 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	8,079,304	79,622	1.00%	$374,071,758.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	7,178,354	1,122,015	18.53%	$332,302,144.00
BlackRock, Inc.	31 Dec, 2025	3,871,639	379,387	10.86%	$179,256,886.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,322,799	1,010,704	43.71%	$153,845,595.00
VANGUARD GROUP INC	31 Dec, 2025	3,060,361	253,212	9.02%	$141,694,714.00
Avoro Capital Advisors LLC	31 Dec, 2025	2,900,000	322,223	12.50%	$134,270,000.00
STATE STREET CORP	31 Dec, 2025	2,649,626	476,590	21.93%	$122,677,684.00
Nantahala Capital Management, LLC	31 Dec, 2025	1,314,002	450,239	52.13%	$60,838,293.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	1,270,321	14,095	1.12%	$58,815,862.00
Commodore Capital LP	31 Dec, 2025	1,200,000	-150,000	-11.11%	$55,560,000.00
BRAIDWELL LP	31 Dec, 2025	1,187,859	-94,130	-7.34%	$54,997,872.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,163,338	78,386	7.22%	$53,870,660.00
Polar Capital Holdings Plc	31 Dec, 2025	1,136,929	-54,194	-4.55%	$52,639,813.00
Woodline Partners LP	31 Dec, 2025	1,111,778	840,946	310.50%	$51,475,321.00
Deep Track Capital, LP	31 Dec, 2025	1,000,000	1,000,000	0.00%	$46,300,000.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	963,050	317,612	49.21%	$44,589,215.00
Vivo Capital, LLC	31 Dec, 2025	894,909	-1,383,294	-60.72%	$41,434,287.00
READYSTATE ASSET MANAGEMENT LP	31 Dec, 2025	874,447	668,640	324.89%	$40,486,896.00
FRANKLIN RESOURCES INC	31 Dec, 2025	823,958	-11,793	-1.41%	$38,149,268.00
Pictet Asset Management Holding SA	31 Dec, 2025	624,128	73,504	13.35%	$28,897,126.00

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