Soleno Therapeutics Inc (SLNO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

54,921,916Shares Outstanding

65,548,476Shares held by institutions

$3,445,883,383Value of institutional holdings

119.35%Institutional ownership %

18.08%Shares Changed QoQ

244No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Soleno Therapeutics Inc (NASDAQ:SLNO) has 244 institutional investors that have filed 13F reports for the period ending December 2025.

Collectively, these holders controlled 112.2% of Soleno Therapeutics's outstanding shares in December 2025, down from 121.4% in September 2025.
They increased total shares held in Soleno Therapeutics by 11.42% from last quarter, and the number of investors in SLNO increased 49.69% annually.
Activity in SLNO broke down as 163 buyers, 64 sellers, and 17 unchanged among 244 total holders.
Institutional investors collectively held 61.61Mn shares in Soleno Therapeutics as of December 2025, up by 6.32Mn shares quarter on quarter, and up 10.01Mn shares year over year.
As of December 31, 2025, the biggest holder of Soleno Therapeutics is FMR LLC at 8.08Mn shares, representing 14.71% of shares outstanding.
The largest buyers of Soleno Therapeutics for the quarter ending December 2025 were Avoro Capital Advisors LLC (3.22Mn), Goldman Sachs Group Inc (1.27Mn), Janus Henderson Group Plc (1.12Mn), WELLINGTON MANAGEMENT GROUP LLP (1.01Mn), Deep Track Capital, LP (1.0Mn).
Top sellers of SLNO stock for the quarter ending December 2025 included Vivo Capital, LLC (1.38Mn), Artia Global Partners LP (810.65K), Jpmorgan Chase & Co (699.37K), Capital World Investors (678.99K), Invesco Ltd. (625.51K).
Business Quant data shows the 10 biggest positions in Soleno Therapeutics as of December 2025 are held by FMR LLC (8.08Mn), Janus Henderson Group Plc (7.18Mn), Avoro Capital Advisors LLC (5.8Mn), BlackRock, Inc. (3.87Mn), WELLINGTON MANAGEMENT GROUP LLP (3.32Mn), VANGUARD GROUP INC (3.06Mn), State Street Corp (2.65Mn), Goldman Sachs Group Inc (1.83Mn), Nantahala Capital Management, LLC (1.31Mn), MILLENNIUM MANAGEMENT LLC (1.24Mn).

244 Institutional Holders

65,548,476 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	8,079,304	79,622	1.00%	$374,071,758.00
Janus Henderson Group Plc	31 Dec, 2025	7,178,354	1,122,015	18.53%	$332,302,144.00
Avoro Capital Advisors LLC	31 Dec, 2025	5,800,000	3,222,223	125.00%	$268,540,000.00
BlackRock, Inc.	31 Dec, 2025	3,871,639	379,387	10.86%	$179,256,886.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,322,799	1,010,704	43.71%	$153,845,595.00
VANGUARD GROUP INC	31 Dec, 2025	3,060,361	253,212	9.02%	$141,694,714.00
State Street Corp	31 Dec, 2025	2,649,626	476,590	21.93%	$122,677,684.00
Goldman Sachs Group Inc	31 Dec, 2025	1,826,100	1,270,662	228.77%	$84,548,430.00
Nantahala Capital Management, LLC	31 Dec, 2025	1,314,002	450,239	52.13%	$60,838,293.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	1,236,321	256,495	26.18%	$57,241,662.00
Commodore Capital LP	31 Dec, 2025	1,200,000	-150,000	-11.11%	$55,560,000.00
BRAIDWELL LP	31 Dec, 2025	1,187,859	-94,130	-7.34%	$54,997,872.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,163,338	78,386	7.22%	$53,870,660.00
Polar Capital Holdings Plc	31 Dec, 2025	1,136,929	-54,194	-4.55%	$52,639,813.00
Woodline Partners LP	31 Dec, 2025	1,111,778	840,946	310.50%	$51,475,321.00
Deep Track Capital, LP	31 Dec, 2025	1,000,000	1,000,000	0.00%	$46,300,000.00
Vivo Capital, LLC	31 Dec, 2025	894,909	-1,383,294	-60.72%	$41,434,287.00
Invesco Ltd.	31 Dec, 2025	875,019	-625,506	-41.69%	$40,513,380.00
READYSTATE ASSET MANAGEMENT LP	31 Dec, 2025	874,447	668,640	324.89%	$40,486,896.00
Franklin Resources Inc	31 Dec, 2025	823,958	-11,793	-1.41%	$38,149,268.00

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