MBX Biosciences, Inc. (MBX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

34,314,286Shares Outstanding

15,569,193Shares held by institutions

$613,114,820Value of institutional holdings

136.21%Institutional ownership %

6.47%Shares Changed QoQ

132No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 132 institutional investors hold a position in MBX Biosciences, Inc. (NASDAQ:MBX).

These investors collectively held 136.2% of the company's total shares outstanding in December 2025, down from 140.7% in September 2025.
The company experienced a 6.47% quarterly change in institutional shares held, alongside an increase of 112.90% in total owners annually.
During the quarter, 93 institutions bought more MBX Biosciences shares, 25 sold shares, and 14 of the 132 total investors held their position steady.
Collectively, institutional investors increased their stake in MBX Biosciences to 46.74Mn shares as of December 2025, a change that is up by 2.84Mn shares quarter on quarter and up 15.97Mn shares year over year.
With 6.65Mn shares, Frazier Life Sciences Management, L.P. commands the largest institutional position in MBX Biosciences as of December 31, 2025, equating to 19.39% of the company.
Among the most significant buyers of MBX Biosciences during December 2025 were BRAIDWELL LP (1.02Mn), BlackRock, Inc. (962.29K), EVENTIDE ASSET MANAGEMENT, LLC (890.00K), D. E. Shaw & Co., Inc. (671.84K), STATE STREET CORP (353.47K).
Leading sellers of MBX Biosciences stock in December 2025 included WELLINGTON MANAGEMENT GROUP LLP (1.47Mn), Kynam Capital Management, LP (1.07Mn), MILLENNIUM MANAGEMENT LLC (218.37K), Woodline Partners LP (201.09K), CITADEL ADVISORS LLC (186.23K).
The top 10 institutional holders of MBX Biosciences for the quarter ending December 2025 included Frazier Life Sciences Management, L.P. (6.65Mn), ORBIMED ADVISORS LLC (3.94Mn), NEA Management Company, LLC (3.61Mn), WELLINGTON MANAGEMENT GROUP LLP (3.35Mn), Deep Track Capital, LP (3.25Mn), BlackRock, Inc. (2.92Mn), NVP Associates, LLC (2.14Mn), EcoR1 Capital, LLC (2.12Mn), VANGUARD GROUP INC (1.82Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.41Mn).

132 Institutional Holders

15,569,193 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Frazier Life Sciences Management, L.P.	31 Dec, 2025	6,652,013	0	0.00%	$209,804,490.00
ORBIMED ADVISORS LLC	31 Dec, 2025	3,935,203	-67,684	-1.69%	$124,116,303.00
NEA Management Company, LLC	31 Dec, 2025	3,614,486	0	0.00%	$114,000,888.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,349,961	-1,473,375	-30.55%	$105,657,771.00
Deep Track Capital, LP	31 Dec, 2025	3,249,790	99,790	3.17%	$102,498,377.00
BlackRock, Inc.	31 Dec, 2025	2,919,756	962,295	49.16%	$92,089,105.00
NVP Associates, LLC	31 Dec, 2025	2,136,335	0	0.00%	$67,380,006.00
EcoR1 Capital, LLC	31 Dec, 2025	2,123,604	0	0.00%	$66,978,470.00
VANGUARD GROUP INC	31 Dec, 2025	1,817,811	140,449	8.37%	$57,333,759.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,408,159	-131,480	-8.54%	$44,413,335.00
Cormorant Asset Management, LP	31 Dec, 2025	1,120,000	-105,000	-8.57%	$35,324,800.00
BRAIDWELL LP	31 Dec, 2025	1,018,600	1,018,600	0.00%	$32,126,644.00
Woodline Partners LP	31 Dec, 2025	1,000,063	-201,087	-16.74%	$31,541,987.00
Kynam Capital Management, LP	31 Dec, 2025	934,799	-1,065,201	-53.26%	$29,483,560.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	890,000	890,000	0.00%	$28,070,600.00
CITADEL ADVISORS LLC	31 Dec, 2025	809,857	-186,226	-18.70%	$25,542,890.00
Point72 Asset Management, L.P.	31 Dec, 2025	680,609	52,942	8.43%	$21,466,408.00
STATE STREET CORP	31 Dec, 2025	672,740	353,466	110.71%	$21,218,220.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	671,838	671,838	0.00%	$21,189,771.00
TCG Crossover Management, LLC	31 Dec, 2025	650,000	0	0.00%	$20,501,000.00

1 - 20 of 132

Research Tools