IO Biotech, Inc. (IOBT) Institutional Ownership

Ownership Summary

Their combined ownership stood at 11.8% of outstanding shares in December 2025, down from 15.7% in September 2025.

• They decreased total shares held in IO Biotech by -21.98% from the prior quarter, while the number of investors in IOBT decreased 18.52% year over year.
• Activity in IOBT broke down as 9 buyers, 8 sellers, and 5 unchanged among 22 total holders.
• Combined, these investors held 7.87Mn shares in IOBT for December 2025, down by 2.22Mn shares quarter on quarter, and down 11.63Mn shares year over year.
• Novo Holdings A/S is the top holder of IO Biotech as of December 31, 2025, with 2.51Mn shares representing 3.75% of outstanding stock.
• The biggest buyers of IO Biotech for the quarter ending December 2025 included Beacon Pointe Advisors, LLC (506.0K), Dauntless Investment Group, LLC (451.64K), Citigroup Inc (110.16K), ADAR1 Capital Management, LLC (49.93K), TWO SIGMA SECURITIES, LLC (44.76K).
• The biggest sellers of IO Biotech for the quarter ending December 2025 included MILLENNIUM MANAGEMENT LLC (1.25Mn), Bank Of America Corp /De/ (799.95K), MARSHALL WACE, LLP (623.29K), RENAISSANCE TECHNOLOGIES LLC (339.71K), BOOTHBAY FUND MANAGEMENT, LLC (139.33K).
• Per Business Quant, the top 10 investors in IOBT for the quarter ending December 2025 include Novo Holdings A/S (2.51Mn), Ikarian Capital, LLC (1.39Mn), Bank Of America Corp /De/ (799.95K), Morgan Stanley (539.18K), Beacon Pointe Advisors, LLC (506.0K), BOOTHBAY FUND MANAGEMENT, LLC (451.85K), Dauntless Investment Group, LLC (451.64K), MARSHALL WACE, LLP (429.34K), RENAISSANCE TECHNOLOGIES LLC (207.6K), MILLENNIUM MANAGEMENT LLC (138.72K).