Esperion Therapeutics, Inc. (ESPR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

195,983,333Shares Outstanding

576,927Shares held by institutions

$2,048,091Value of institutional holdings

78.25%Institutional ownership %

49.53%Shares Changed QoQ

191No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 191 institutions have reported a stake in Esperion Therapeutics, Inc. (NASDAQ:ESPR) as of December 2025, according to recent 13F filings with the SEC.

These investors collectively held 78.3% of the company's total shares outstanding in December 2025, up from 55.2% in September 2025.
In percentage terms, this reflects as a holdings change of 49.53% quarter on quarter, and an increase of 1.06% year over year.
The latest 13F cycle for Esperion Therapeutics reveals that of 191 total investors, 118 funds grew their exposure, whereas 35 reduced theirs and 38 made no changes.
The aggregate institutional position in Esperion Therapeutics now stands at 153.37Mn shares as of December 2025, after investors increased their holdings (up by 50.80Mn shares quarter on quarter which is up 20.14Mn shares year over year).
With 17.68Mn shares, BlackRock, Inc. commands the largest institutional position in Esperion Therapeutics as of December 31, 2025, equating to 9.02% of the company.
Among the most significant buyers of Esperion Therapeutics during December 2025 were D. E. Shaw & Co., Inc. (6.69Mn), ORBIMED ADVISORS LLC (5.97Mn), Eversept Partners, LP (3.85Mn), MILLENNIUM MANAGEMENT LLC (2.96Mn), MARSHALL WACE, LLP (2.95Mn).
Leading sellers of Esperion Therapeutics stock in December 2025 included PenderFund Capital Management Ltd. (2.28Mn), UBS Group AG (932.96K), ROYAL BANK OF CANADA (900.66K), CITADEL ADVISORS LLC (780.26K), MORGAN STANLEY (541.40K).
The top 10 institutional holders of Esperion Therapeutics for the quarter ending December 2025 included BlackRock, Inc. (17.68Mn), VANGUARD GROUP INC (14.95Mn), Two Seas Capital LP (11.90Mn), WASATCH ADVISORS LP (9.45Mn), D. E. Shaw & Co., Inc. (6.90Mn), ORBIMED ADVISORS LLC (5.97Mn), STATE STREET CORP (5.93Mn), GEODE CAPITAL MANAGEMENT, LLC (5.74Mn), MARSHALL WACE, LLP (5.47Mn), TWO SIGMA INVESTMENTS, LP (4.74Mn).

191 Institutional Holders

576,927 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	17,682,201	2,848,410	19.20%	$65,424,144.00
VANGUARD GROUP INC	31 Dec, 2025	14,945,454	2,853,005	23.59%	$55,298,179.00
Two Seas Capital LP	31 Dec, 2025	11,902,521	2,152,797	22.08%	$44,039,328.00
WASATCH ADVISORS LP	31 Dec, 2025	9,445,759	2,383,902	33.76%	$34,949,308.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	6,903,483	6,694,850	3,208.91%	$25,542,887.00
ORBIMED ADVISORS LLC	31 Dec, 2025	5,965,498	5,965,498	0.00%	$22,072,343.00
STATE STREET CORP	31 Dec, 2025	5,930,296	1,451,462	32.41%	$21,942,095.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,737,651	986,255	20.76%	$21,233,711.00
MARSHALL WACE, LLP	31 Dec, 2025	5,471,611	2,950,172	117.00%	$20,244,963.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	4,742,082	2,503,464	111.83%	$17,545,703.00
PenderFund Capital Management Ltd.	31 Dec, 2025	4,391,926	-2,284,593	-34.22%	$16,250,126.00
AIGH Capital Management LLC	31 Dec, 2025	4,000,000	1,000,000	33.33%	$14,800,000.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	3,932,274	2,957,418	303.37%	$14,549,414.00
Eversept Partners, LP	31 Dec, 2025	3,851,133	3,851,133	0.00%	$14,249,192.00
Nuveen, LLC	31 Dec, 2025	3,612,113	-98,956	-2.67%	$13,364,818.00
ROYCE & ASSOCIATES LP	31 Dec, 2025	3,601,523	1,308,035	57.03%	$13,325,635.00
MORGAN STANLEY	31 Dec, 2025	3,514,227	-541,399	-13.35%	$13,002,640.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	3,505,200	1,597,200	83.71%	$12,969,240.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	2,848,216	1,139,409	66.68%	$10,538,400.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	2,194,600	1,420,700	183.58%	$8,120,020.00

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