Esperion Therapeutics, Inc. (ESPR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

200,736,136Shares Outstanding

153,943,195Shares held by institutions

$295,570,934Value of institutional holdings

76.69%Institutional ownership %

46.27%Shares Changed QoQ

195No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Esperion Therapeutics, Inc. (NASDAQ:ESPR) showed up in the 13F filings of 195 institutional investors as of December 2025.

Their combined ownership stood at 75.3% of outstanding shares in December 2025, up from 54.4% in September 2025.
They increased total shares held in Esperion Therapeutics by 44.43% from the prior quarter, while the number of investors in ESPR increased 4.28% year over year.
During the quarter, 122 of these 195 funds increased positions in ESPR, 35 reduced exposure, and 38 held steady.
The aggregate institutional position in Esperion Therapeutics amounted to 151.08Mn shares as of December 2025, up by 46.47Mn shares quarter on quarter, and up 11.46Mn shares year over year.
As of December 31, 2025, the biggest holder of Esperion Therapeutics is BlackRock, Inc. at 17.68Mn shares, representing 8.81% of shares outstanding.
The biggest buyers of Esperion Therapeutics for the quarter ending December 2025 included D. E. Shaw & Co., Inc. (6.69Mn), ORBIMED ADVISORS LLC (5.97Mn), Goldman Sachs Group Inc (3.99Mn), Eversept Partners, LP (3.85Mn), MILLENNIUM MANAGEMENT LLC (2.96Mn).
The biggest sellers of Esperion Therapeutics for the quarter ending December 2025 included PenderFund Capital Management Ltd. (2.28Mn), UBS Group AG (932.96K), Jpmorgan Chase & Co (925.92K), Royal Bank Of Canada (900.66K), JANE STREET GROUP, LLC (872.32K).
Esperion Therapeutics's 10 largest shareholders as of December 2025 include BlackRock, Inc. (17.68Mn), VANGUARD GROUP INC (14.95Mn), Two Seas Capital LP (11.9Mn), WASATCH ADVISORS LP (9.45Mn), D. E. Shaw & Co., Inc. (6.9Mn), ORBIMED ADVISORS LLC (5.97Mn), State Street Corp (5.93Mn), GEODE CAPITAL MANAGEMENT, LLC (5.74Mn), Goldman Sachs Group Inc (5.7Mn), MARSHALL WACE, LLP (5.47Mn) per Business Quant data.

195 Institutional Holders

153,943,195 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	17,682,201	2,848,410	19.20%	$65,424,144.00
VANGUARD GROUP INC	31 Dec, 2025	14,945,454	2,853,005	23.59%	$55,298,179.00
Two Seas Capital LP	31 Dec, 2025	11,902,521	2,152,797	22.08%	$44,039,328.00
WASATCH ADVISORS LP	31 Dec, 2025	9,445,759	2,383,902	33.76%	$34,949,308.00
D. E. Shaw & Co., Inc.	31 Dec, 2025	6,903,483	6,694,850	3,208.91%	$25,542,887.00
ORBIMED ADVISORS LLC	31 Dec, 2025	5,965,498	5,965,498	0.00%	$22,072,343.00
State Street Corp	31 Dec, 2025	5,930,296	1,451,462	32.41%	$21,942,095.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	5,737,651	986,255	20.76%	$21,233,711.00
Goldman Sachs Group Inc	31 Dec, 2025	5,696,432	3,987,625	233.36%	$21,076,800.00
MARSHALL WACE, LLP	31 Dec, 2025	5,471,611	2,950,172	117.00%	$20,244,963.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	4,742,082	2,503,464	111.83%	$17,545,703.00
PenderFund Capital Management Ltd.	31 Dec, 2025	4,391,926	-2,284,593	-34.22%	$16,250,126.00
AIGH Capital Management LLC	31 Dec, 2025	4,000,000	1,000,000	33.33%	$14,800,000.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	3,932,274	2,957,418	303.37%	$14,549,414.00
Eversept Partners, LP	31 Dec, 2025	3,851,133	3,851,133	0.00%	$14,249,192.00
Nuveen, LLC	31 Dec, 2025	3,612,113	-98,956	-2.67%	$13,364,818.00
ROYCE & ASSOCIATES LP	31 Dec, 2025	3,601,523	1,308,035	57.03%	$13,325,635.00
Morgan Stanley	31 Dec, 2025	3,514,227	-541,399	-13.35%	$13,002,640.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	3,505,200	1,597,200	83.71%	$12,969,240.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	2,194,600	1,420,700	183.58%	$8,120,020.00

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