Centessa Pharmaceuticals plc (CNTA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

133,880,488Shares Outstanding

30,138,099Shares held by institutions

$751,644,189Value of institutional holdings

104.68%Institutional ownership %

16.07%Shares Changed QoQ

145No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Centessa Pharmaceuticals plc (NASDAQ:CNTA) currently has 145 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Centessa Pharmaceuticals moved to 104.7% in December 2025, a shift up from the 96.7% reported for September 2025.
Quarterly data indicates a 16.07% shift in institutional share volume, and the annual owner count reflects an increase of 27.19%.
Of these 145 institutional investors, 89 increased their holdings in Centessa Pharmaceuticals, while 45 of them reduced positions, and 11 investors maintained their exposure.
The total number of shares held by institutions in Centessa Pharmaceuticals increased to 140.14Mn as of December 2025, a net change of up by 19.40Mn shares quarter on quarter, and up 16.29Mn shares year over year.
The top institutional stake in Centessa Pharmaceuticals as of December 31, 2025 belongs to Medicxi Ventures Management (Jersey) Ltd, which owns 19.96Mn shares, or 14.91% of the company.
Among the most significant buyers of Centessa Pharmaceuticals during December 2025 were Avoro Capital Advisors LLC (3.75Mn), FMR LLC (2.68Mn), EcoR1 Capital, LLC (2.56Mn), BRAIDWELL LP (2.19Mn), Deep Track Capital, LP (2.00Mn).
Leading sellers of Centessa Pharmaceuticals stock in December 2025 included GENERAL ATLANTIC, L.P. (3.56Mn), Commodore Capital LP (1.85Mn), First Light Asset Management, LLC (1.36Mn), JANUS HENDERSON GROUP PLC (1.31Mn), Caption Management, LLC (756.01K).
The top 10 institutional holders of Centessa Pharmaceuticals for the quarter ending December 2025 included Medicxi Ventures Management (Jersey) Ltd (19.96Mn), Avoro Capital Advisors LLC (14.56Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (11.28Mn), Index Venture Life Associates VI Ltd (9.96Mn), FMR LLC (8.96Mn), GENERAL ATLANTIC, L.P. (6.12Mn), FARALLON CAPITAL MANAGEMENT LLC (5.38Mn), TCG Crossover Management, LLC (4.29Mn), JANUS HENDERSON GROUP PLC (4.09Mn), Siren, L.L.C. (4.03Mn).

145 Institutional Holders

30,138,099 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Medicxi Ventures Management (Jersey) Ltd	31 Dec, 2025	19,963,157	0	0.00%	$499,278,557.00
Avoro Capital Advisors LLC	31 Dec, 2025	14,555,555	3,747,475	34.67%	$364,034,431.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	11,281,741	1,246,741	12.42%	$282,156,342.00
Index Venture Life Associates VI Ltd	31 Dec, 2025	9,961,789	0	0.00%	$249,144,343.00
FMR LLC	31 Dec, 2025	8,961,939	2,684,696	42.77%	$224,138,094.00
GENERAL ATLANTIC, L.P.	31 Dec, 2025	6,117,715	-3,564,103	-36.81%	$153,004,052.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	5,377,068	1,045,750	24.14%	$134,480,471.00
TCG Crossover Management, LLC	31 Dec, 2025	4,286,480	1,150,000	36.67%	$107,204,865.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	4,093,608	-1,314,591	-24.31%	$102,393,318.00
Siren, L.L.C.	31 Dec, 2025	4,027,517	800,000	24.79%	$100,728,200.00
EcoR1 Capital, LLC	31 Dec, 2025	3,115,000	2,565,000	466.36%	$77,906,150.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	2,917,634	-183,268	-5.91%	$72,970,026.00
FRANKLIN RESOURCES INC	31 Dec, 2025	2,368,381	-190,033	-7.43%	$59,233,201.00
FEDERATED HERMES, INC.	31 Dec, 2025	2,342,139	592,489	33.86%	$58,576,896.00
First Light Asset Management, LLC	31 Dec, 2025	2,278,940	-1,356,876	-37.32%	$56,996,289.00
BRAIDWELL LP	31 Dec, 2025	2,188,320	2,188,320	0.00%	$54,729,883.00
Deep Track Capital, LP	31 Dec, 2025	2,000,000	2,000,000	0.00%	$50,020,000.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	1,870,671	918,403	96.44%	$46,785,482.00
RTW INVESTMENTS, LP	31 Dec, 2025	1,790,837	-500,910	-21.86%	$44,788,833.00
MAVERICK CAPITAL LTD	31 Dec, 2025	1,643,724	1,643,724	0.00%	$41,109,537.00

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